Author

Joshua J. Deppas

University of PittsburghORCID 0000-0002-9093-7459Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Christopher J. BakkenistiD· 2 shared Frank P. VendettiiD· 2 shared Jan Hendrik BeumeriD· 2 shared Pinakin PandyaiD· 2 shared Anthony V. Columbus· 1 shared Brian F. KieseliD· 1 shared Daniel IvanoviD· 1 shared David A Clump· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Christopher J. BakkenistORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 28, 2026

Transient ATR inhibition following ionizing radiation enhances immune-mediated antitumor response and survival

Joshua J. Deppas, Brian F. Kiesel, Frank P. Vendetti…·Jan Hendrik Beumer

The paper shows that transient ATR inhibition with ceralasertib and elimusertib, but not berzosertib, enhances antitumor immune responses and survival when combined with ionizing radiation in a mouse model.

DOI 10.64898/2026.05.25.727700

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintApr 4, 2024

Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

Pinakin Pandya, Frank P. Vendetti, Joseph El-Ghoubaira…·Christopher J. Bakkenist

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

2 citations

mouseDNA methylation

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