Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory
Claire C. Chen, Joseph Han, Carlene A. Chinn, Jacob S. Rounds, Xiang Li, Mehran Nikan, Marie Myszka, Liqi Tong, Luiz F. M. Passalacqua, Timothy William Bredy, Marcelo A. Wood, Andrej Lupták
The paper shows that inhibiting the CPEB3 ribozyme increases CPEB3 protein and enhances memory by promoting mRNA polyadenylation and translation.
eLife · Feb 6, 2024Peer-reviewedNeuroscience