Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multi-site polarity substrate Lgl
Christopher P. Earl, Mathias Cobbaut, André Barros-Carvalho, Marina E. Ivanova, David C. Briggs, Eurico Morais‐de‐Sá, Peter J. Parker, Neil Q. McDonald
The paper reports the structure of aPKC-Par6 bound to Lgl1 and proposes a model for its mutual inhibition and release mechanism in cell polarity.
Nature Structural & Molecular Biology · Jan 6, 2025Peer-reviewedBiochemistry