Cancer BiologyScience SignalingPeer-reviewed
The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.
Véronique Calleja, Jack C. Henry, Mathias Cobbaut…·Peter J. Parker
The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.
1 citation