Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids
Natalia López-Anguita, Seher Ipek Gassaloglu, Maximilian Stötzel, Marina Typou, Iiris Virta, Sara Hetzel, René Buschow, Burak Koksal, Derya Atilla, Ronald Maitschke-Rajasekharan, Rui Chen, Alexandra L. Mattei, Ivan Bedzhov, David Meierhofer, Alexander Meissner, , Aydan Bulut-Karslıoğlu
The paper shows hypoxia induces an early primitive streak signature in ES cells, enhancing gastruloid elongation and lineage representation through Hif1-mediated transcriptional changes.
Development · Sep 14, 2022Peer-reviewedDevelopmental Biology