Ivan Bedzhov

Shield-4i: A Whole-mount Multiplexed Imaging Platform for Studying Multiscale Information Flow in 3D Multicellular Systems

Shield-4i enables high-throughput, subcellular-resolution imaging of whole-mount structures to study multiscale information flow in multicellular systems.

Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos

The paper identifies the role of Oct4 and Sox2 in establishing the pluripotency network in early mouse embryos through chromatin and transcriptome analysis.

Tissue-intrinsic Wnt signals antagonize Nodal-driven AVE differentiation

The paper shows that Wnt signaling within the visceral endoderm restricts AVE differentiation, independent of BMP gradients, using mouse stem cell aggregates.

Enhancing Sox/Oct cooperativity induces higher-grade developmental reset

This study identifies a Sox2 mutation that enhances Sox/Oct cooperativity, improving iPSC reprogramming efficiency and enabling reprogramming of aged cells across species.

Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids

The paper shows hypoxia induces an early primitive streak signature in ES cells, enhancing gastruloid elongation and lineage representation through Hif1-mediated transcriptional changes.