Author

Maris Handley

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anna KiemiD· 2 shared Emane Rose AssitaiD· 2 shared Marissa D. FahlbergiD· 2 shared Michael C. MazzolaiD· 2 shared Sarah ForwardiD· 2 shared Sheldon J. J. KwokiD· 2 shared Abdalla M. AlbeelyiD· 1 shared Abraham A. PalmeriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersDevelopmental Biology

Anna KiemORCID

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Author profile →

3 papers

Recent·Most cited

Differentiation stage-specific use of cap-independent and cap-dependent translation initiation in hematopoiesis

Michael C. Mazzola, Ting Zhao, Anna Kiem, Trine Ahn Kristiansen, Karin Gustafsson, Lai Ping Wong, Emily Scott-Solomon, Marissa D. Fahlberg, Sarah Forward, Emane Rose Assita, Giulia Schiroli, Maris Handley, Youmna Sami Kfoury, Tsuyoshi Fukushima, Samuel Keyes, , David T. Scadden

The paper shows that IRES/Cap translation increases during hematopoietic and epithelial differentiation under normal conditions, correlating with lower stemness.

bioRxiv · Sep 24, 2025 · PreprintDevelopmental Biology

Aberrant recursive splicing in a human disease locus

Philip M. Boone, Ricardo Harripaul, Rachita Yadav, Michael N. Grzybowski, Mahmoud K. Hanafy, Amanda C. Lee, Esther Y. Choi, Ryan L. Collins, Oksana Polesskaya, Nina R. Makhortova, Matthew O. Larson, Hakan Kayır, Yizhi Wang, Rodolfo A. Avila, Jude A. Frie, , Michael E. Talkowski

The paper investigates the functional role of recursive splicing in CADM2, showing that its deletion leads to altered gene expression and behavioral changes in neurodevelopmental disorders.

bioRxiv · Aug 14, 2025 · PreprintGenomics

Overcoming fixation and permeabilization challenges in flow cytometry by optical barcoding and multi-pass acquisition

Marissa D. Fahlberg, Sarah Forward, Emane Rose Assita, Michael C. Mazzola, Anna Kiem, Maris Handley, Seok Hyun Yun, Sheldon J. J. Kwok

This paper introduces a multi-pass flow cytometry technique that enables sequential analysis of cells before and after fixation/permeabilization, improving measurement accuracy for fragile biomarkers.

Cytometry Part A · Oct 28, 2024Peer-reviewedBioengineering