Michael C. Mazzola

Differentiation stage-specific use of cap-independent and cap-dependent translation initiation in hematopoiesis

The paper shows that IRES/Cap translation increases during hematopoietic and epithelial differentiation under normal conditions, correlating with lower stemness.

Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

Hematopoietic stem cells undergo bidirectional fate transitions in vivo

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

Overcoming fixation and permeabilization challenges in flow cytometry by optical barcoding and multi-pass acquisition

This paper introduces a multi-pass flow cytometry technique that enables sequential analysis of cells before and after fixation/permeabilization, improving measurement accuracy for fragile biomarkers.