Author

Mariska E. Keizer

Leiden University Medical Center

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Dmitri V. FilippoviD· 1 shared Douwe J. DijkstraiD· 1 shared Dylan P. NooneiD· 1 shared Jip WulffeléiD· 1 shared Leendert Adrianus TrouwiD· 1 shared Marjolein M. E. IsendoorniD· 1 shared Sebastiaan M. W. R. HamersiD· 1 shared Thomas Harry SharpiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Dmitri V. FilippovORCID

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1 paper

Recent·Most cited

Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, Douwe J. Dijkstra, Leendert Adrianus Trouw, Dmitri V. Filippov, Thomas Harry Sharp

This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.

Proceedings of the National Academy of Sciences · Sep 6, 2024Peer-reviewedImmunology