Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, Douwe J. Dijkstra, Leendert Adrianus Trouw, Dmitri V. Filippov, Thomas Harry Sharp
This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.
Proceedings of the National Academy of Sciences · Sep 6, 2024Peer-reviewedImmunology