Mass-selective and ice-free cryo-EM protein sample preparation via native electrospray ion-beam deposition
Tim K. Esser, Jan Böhning, Paul Fremdling, Mark T. Agasid, Adam J. Costin, Kyle L. Fort, Albert Konijnenberg, Joshua D. Gilbert, Alan S. Bahm, Alexander Makarov, Carol V. Robinson, Justin L. P. Benesch, Lindsay A. Baker, Tanmay A. M. Bharat, Joseph Gault, Stephan Rauschenbach
This paper introduces native ES-IBD for preparing high-purity, ice-free cryo-EM samples, showing structural integrity but limitations in 2D classes and 3D EM density maps.
PNAS Nexus · Aug 6, 2022Peer-reviewedMolecular Biology