Native Mass Spectrometry Reveals Distinct Effects of Linker Length and Targeting-Ligand Identity on PROTAC Ternary Complexes
Evan N. Whitford, Joshua D. Gilbert, Marius M. Kostelic, Michelle A. Estrada, Aaron C. Ehlinger, Tiffany A. Thibaudeau, Shaun M. McLoughlin, Vicki Hopper Wysocki
This study uses native mass spectrometry to show how PROTAC linker length and targeting ligand affect ternary complex structure and stability.
bioRxiv · Sep 30, 2026 · PreprintBiochemistry