Author

Mark Tremelling

Norfolk and Norwich University Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Miles ParkesiD· 3 shared Ailsa Hart· 2 shared Alison Simmons· 2 shared Carl A Anderson· 2 shared Cathryn Edwards· 2 shared Chris Hawkey· 2 shared Christopher A Lamb· 2 shared Christopher G Mathew· 2 shared

Activity by Year

2016-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Miles ParkesORCID

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Author profile →

3 papers

Recent·Most cited

A systems genomics approach to uncover patient-specific pathogenic pathways in a complex disease

Johanne Brooks, Dezso Modos, Padhmanand Sudhakar, David Fazekas, Azedine Zoufir, Orsolya Kapuy, Mate Szalay-Beko, Matthew Madgwick, Bram Verstockt, Lindsay Hall, Alastair J.M. Watson, Mark Tremelling, Miles Parkes, Severine Vermeire, Andreas Bender, , Tamas Douglas Korcsmaros

This paper introduces iSNP, a workflow to identify patient-specific pathogenic pathways in ulcerative colitis by integrating SNP profiles with regulatory networks.

bioRxiv · Jul 4, 2019 · PreprintBioinformatics

Exploring the genetic architecture of inflammatory bowel disease by whole genome sequencing identifies association at ADCY7

Yang Luo, Katrina M de Lange, Luke Jostins, Loukas Moutsianas, Joshua Randall, Nicholas A Kennedy, Christopher A Lamb, Shane McCarthy, Tariq Ahmad, Cathryn Edwards, Eva Goncalves Serra, Ailsa Hart, Chris Hawkey, John C Mansfield, Craig Mowat, , Carl A Anderson

This study uses whole genome sequencing to explore the genetic architecture of inflammatory bowel diseases, identifying a risk variant in ADCY7 for ulcerative colitis but finding limited contribution of low-frequency variants to heritability.

Nature Genetics · Jan 9, 2017Peer-reviewedGenetics

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

Katrina M de Lange, Loukas Moutsianas, James C Lee, Christopher A Lamb, Yang Luo, Nicholas A Kennedy, Luke Jostins, Daniel L Rice, Javier Gutierrez-Achury, Sun-Gou Ji, Graham Heap, Elaine R Nimmo, Cathryn Edwards, Paul Henderson, Craig Mowat, , Jeffrey Barrett

This study identifies 26 new genetic loci associated with inflammatory bowel disease, including integrin genes linked to immune activation and disease risk.

bioRxiv · Jun 10, 2016Genomics