Bram Verstockt

This study identifies molecular subtypes of perianal fistulizing Crohn's disease using multiomics, revealing a psoriasis-like keratinization signature linked to surgical outcomes.

The paper models the impact of non-coding SNPs on gene regulatory networks in IBD to stratify patients based on gene dysregulation and therapeutic response.

The paper investigates resistance to JAK inhibitors in UC by analyzing single-cell RNA data from responders and non-responders, identifying hyperactivation of myeloid cells as a key mechanism.

This study identifies IL-26-expressing MAIT cells as protective for epithelial barrier function and shows their dysregulation in Crohn's disease.

This study uses single-cell RNA-seq data to analyze how SARS-CoV-2 infection alters intestinal epithelial-immune cell interactions and identifies potential drug targets and repurposing strategies for COVID-19.

The paper investigates how intestinal inflammation in IBD affects SARS-CoV-2 entry receptors like ACE2, finding opposing regulation in ileum and colon.

This paper introduces iSNP, a workflow to identify patient-specific pathogenic pathways in ulcerative colitis by integrating SNP profiles with regulatory networks.