PAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis
Thomas H. Sisson, John J. Osterholzer, Lisa Leung, Venkatesha Basrur, Alexey I. Nesvizhskii, Natalya Subbotina, Mark Warnock, Daniel Torrente, Ammara Q Virk, Sergey S Gutor, Jeffrey Craig Horowitz, Mary M. Migliorini, Dudley K. Strickland, Kevin K. Kim, Steven Kenneth Huang, Daniel A. Lawrence
The paper identifies SorlA as a novel PAI-1 interactor required for lung fibrosis, showing SorlA deficiency protects against fibrosis in mice and SorlA is upregulated in human IPF lung tissue.
JCI Insight · Apr 29, 2025Peer-reviewedPathology