Steven Kenneth Huang

HuR Regulates GATA3-Driven Type 2 Inflammation in CD4⁺ T cells and ILC2 in Airway Inflammation

This study identifies HuR as a regulator of GATA3-driven type 2 inflammation in asthma, showing its inhibition reduces lung inflammation and Th2 cytokine production.

Wilms tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions

This study shows WT1 promotes fibroblast survival and ECM production in IPF by impairing apoptotic clearance.

PAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis

The paper identifies SorlA as a novel PAI-1 interactor required for lung fibrosis, showing SorlA deficiency protects against fibrosis in mice and SorlA is upregulated in human IPF lung tissue.

DENetwork: Unveiling Regulatory and Signaling Networks Behind Differentially-Expressed Genes

DENetwork identifies regulatory and signaling networks behind differentially-expressed genes by integrating DE and non-DE genes in a graphical model, enhancing traditional differential gene analysis.

Single-cell RNA-seq analysis of human iPSC-derived motor neurons resolves early and predictive ALS signatures

The paper uses single-cell RNA-seq to identify early ALS signatures in iPSC-derived motor neurons across multiple models and platforms.