WDFY2 restrains matrix metalloprotease secretion and cell invasion by retention of VAMP3 in endosomal tubules
Marte Sneeggen, Nina Marie Pedersen, Coen Campsteijn, Ellen Margrethe Haugsten, Harald Stenmark, Kay Oliver Schink
This study identifies WDFY2 as a tumor suppressor that restricts cell invasion by retaining VAMP3 in endosomal tubules, preventing MT1-MMP secretion and extracellular matrix degradation.
bioRxiv · Apr 13, 2018 · PreprintCell Biology