Toru Suzuki

Protein kinase C inhibitor suppresses 2-cell stage development and perinuclear vesicle formation in mouse zygotes

This study investigates the role of PKC inhibition in mouse zygotes, finding it suppresses 2-cell stage development and perinuclear vesicle formation.

Cell-penetrating peptide-mediated mouse oocyte activation

This study uses a cell-penetrating peptide fused to Emi2 to activate mouse oocytes, showing it can induce pronuclear formation and blastocyst development.

RTL4, a retrovirus-derived gene implicated in autism spectrum disorder, is a microglial gene that responds to noradrenaline in the postnatal brain

This study identifies RTL4 as a microglial gene responsive to noradrenaline, showing its expression dynamics and role in brain adaptation and neuronal network development.

Novel imprints in mouse blastocysts are predominantly DNA methylation independent

The paper identifies novel imprinted genes in mouse blastocysts and shows that their expression is mostly independent of DNA methylation but associated with H3K27me3 marks.

Mouse fertilization triggers a conserved transcription program in one-cell embryos

The paper shows that transcription starts much earlier in mouse and human one-cell embryos than previously thought, driven mainly by the maternal genome.

Switchable genome editing via genetic code expansion

This paper develops a BOC-dependent CRISPR-Cas9 system for controlled genome editing in mammals, enabling heritable edits only after BOC exposure.