Marty T. Mortrud

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

The paper maps brain-wide monosynaptic inputs to specific neuron classes in mouse visual cortex using an improved rabies virus tracing strategy and identifies connectivity patterns within and between visual areas.

The paper develops enhancer viruses and a transgenic mouse line to enable combinatorial labeling of specific neuronal subclasses in the mouse cortex and human slices.

The paper identifies enhancer elements that drive subclass-specific gene expression in neocortex across mouse, primate, and human species using comparative epigenetics and AAV-based functional assays.

The paper expands the Allen Mouse Brain Connectivity Atlas by analyzing intracortical connections at the layer and cell class level, revealing modular organization and distinct projection patterns.

The paper introduces a light-inducible recombinase system for targeted genomic modifications in neurons, enabling precise labeling and functional analysis of neural circuits in live mouse brains.