Ali H. Cetin

TRU-FACT aligns in vivo imaging and spatial biology datasets at cellular resolution to link cellular dynamics with molecular attributes.

This study maps the cell-type-specific afferent and efferent projections of the mouse claustrum using viral tracing and single-neuron reconstruction, revealing its widespread connections and regional specificity.

The paper maps brain-wide monosynaptic inputs to specific neuron classes in mouse visual cortex using an improved rabies virus tracing strategy and identifies connectivity patterns within and between visual areas.

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

The paper develops enhancer viruses and a transgenic mouse line to enable combinatorial labeling of specific neuronal subclasses in the mouse cortex and human slices.

The paper identifies enhancer elements that drive subclass-specific gene expression in neocortex across mouse, primate, and human species using comparative epigenetics and AAV-based functional assays.

The paper discusses strategies for targeted neuronal manipulation using adeno-associated virus (AAV) and other technologies, emphasizing best practices and future directions.

The paper introduces a light-inducible recombinase system for targeted genomic modifications in neurons, enabling precise labeling and functional analysis of neural circuits in live mouse brains.

The paper maps the connectivity of VMHvlEsr1 neurons in mice, revealing distinct subpopulations with different collateralization patterns but similar inputs, suggesting a unique circuit architecture for social behavior control.

The paper identifies shared and distinct transcriptomic cell types in two mouse neocortical regions using scRNA-seq, showing most excitatory types are region-specific while inhibitory types are shared.

SmartScope2 is an automated neuron reconstruction tool that reduces image data requirements and increases imaging speed for human and mouse cortical neurons.