James J. Galligan

A Paracrine Dietary Lipid Axis Constrains Antitumor Immunity in Liver Cancer

This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

Non-enzymatic RNA Glycation is a Metabolic Sensor of Cellular Stress

This study identifies mRNA glycation by methylglyoxal as a metabolic stress sensor, showing impaired translation and beta-cell dysfunction, which is mitigated by metformin.

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis

This study shows that dietary sulfur amino acid restriction improves glucose homeostasis by enhancing hepatic de novo serine synthesis through PSAT1, but not lipid metabolism.

Growth Hormone Excess Drives Liver Aging via increased Glycation stress

This study shows that growth hormone excess in mice causes liver aging by increasing glycation stress, which can be reversed with glycation-lowering compounds.

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

This study shows that doxorubicin chemotherapy induces aortic stiffening via cellular senescence and the senescence-associated secretory phenotype, which can be mitigated by senolytic therapy.

txci-ATAC-seq, a massive-scale single-cell technique to profile chromatin accessibility

The paper introduces txci-ATAC-seq, a high-throughput single-cell ATAC-seq method, and demonstrates its application across multiple tissues and genetic backgrounds.

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

This study identifies MG-H1 as a mediator of increased food intake in C. elegans glod-4 mutants through a tyramine signaling pathway regulated by the GATA transcription factor ELT-3.