Kieu Lam

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

This paper develops programmable protein degraders (uAbs) that selectively knock down pathogenic β-catenin in vitro and in vivo, reducing tumor cell survival and proliferation.

Endogenous antigen processing promotes mRNA vaccine CD4+ T cell responses

This study shows that endogenous antigen processing via MHC II is critical for mRNA-LNP vaccine-induced CD4+ T cell responses, challenging the traditional view of exogenous antigen processing.

Curative levels of endogenous gene replacement achieved in non-human primate liver using programmable genomic integration

This paper demonstrates programmable genomic integration in non-human primate liver, achieving curative levels of gene expression in over 50% of liver cells.