A T-cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
John F. Pell, E. M. Tanvir, Zhengliang Sun, Irene Chernova, Anand Chellappan Reghuvaran, Soichiro Nagata, Mateus Guerra, John Choi, Soltan Al Chaar, Hiroki Mizuno, Ke Dong, Xin Tian, Reika Ishibe, Barbara Franchin, Paolo Cravedi, , Madhav C. Menon
This study identifies a T-cell intrinsic mechanism by which APOL1 risk alleles contribute to kidney rejection through altered calcium signaling and T-cell activation.
American Journal of Transplantation · Aug 1, 2025Peer-reviewedImmunology