Cijiang He

Fosl2 regulates the transition from parietal epithelial cells to myofibroblasts in the kidney

This study identifies Fosl2 as a regulator of PEC-to-myofibroblast transition in kidney disease using mouse models and human biopsies.

A T-cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection

This study identifies a T-cell intrinsic mechanism by which APOL1 risk alleles contribute to kidney rejection through altered calcium signaling and T-cell activation.

Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele.

This study identifies the Shroom3 ASD2-domain as critical for profibrotic function in CKD through ROCK activation, showing motif-specific roles in renal fibrosis and albuminuria.

Genetic polymorphisms of Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3) gene in African American kidney transplant recipients are associated with post-transplant graft failure

The paper identifies four SNPs in the LILRB3 gene associated with graft failure in African American kidney transplant recipients and links them to immune-related diseases.

Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 locus mismatches associated with long-term renal transplant survival

A reference tissue atlas for the human kidney

The paper constructs a reference tissue atlas of the human kidney using multi-omics data to identify cell types, pathways, and genes across nephron segments and interstitium.

AMP-Kinase mediates regulation of glomerular volume and podocyte survival

The paper investigates the role of AMP-Kinase in regulating glomerular volume and podocyte survival through experimental models and biochemical analysis.