4-Nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim
This study shows that 4-nitrobenzoate inhibits 4-HPT in malaria parasites, enhances atovaquone efficacy in vitro and in vivo, and identifies chemical requirements for this potentiation.
FEBS Letters · Oct 14, 2025Peer-reviewedMicrobiology