Targetable Treatment Resistance in Thyroid Cancer with Clonal Hematopoiesis
Vera Tiedje, Pablo Sánchez Vela, Julie L. Yang, Brian R. Untch, Laura Boucai, Aaron James Stonestrom, Alberto Bueno Costa, Sebastià Franch‐Expósito, Avi Srivastava, Marina Kerpelev, Jillian Greenberg, Mathew Wereski, Amanda R. Kulick, Kevin Chen, Tianyue Qin, , Ross L. Levine
This study identifies TET2-mutant clonal hematopoiesis in thyroid cancer microenvironments and shows that TGFβ signaling from these macrophages mediates resistance to BRAF/MEK inhibition, with TGFβ inhibition restoring sensitivity.
bioRxiv · Oct 10, 2024 · PreprintCancer Biology