Chemotherapeutic 6-thio-2-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex
Samantha L. Sanford, Mareike Badstübner, Michael H. Gerber, William P. Mannherz, Noah M. Lampl, Rachel L. Dannenberg, Angela M. Hinchie, Matthew A Schaich, Sua Myong, Mark Hedglin, Suneet Agarwal, Jonathan K. Alder, Michael D. Stone, Patricia Lynn Opresko
This study shows 6-thio-dG inhibits telomerase by forming a non-productive complex, affecting telomere maintenance in cancer cells.
bioRxiv · Feb 5, 2025 · PreprintCancer Biology