Patricia Lynn Opresko

MUTYH activity maintains telomere stability in response to chronic telomeric 8-oxoguanine damage in cancer cells

This study shows MUTYH prevents telomere shortening and genomic instability in cancer cells under chronic 8-oxoG damage by resolving BER intermediates.

Oxidative Base Damage to Telomeres Sensitizes Cancer Cells to ATR Inhibition

This study shows that inducing oxidative base damage at telomeres increases cancer cell sensitivity to ATR inhibition by causing genome instability and reduced viability.

Human ribomes reveal DNA-embedded ribonucleotides as a new type of epigenetic mark

The paper maps DNA-embedded ribonucleotides (rNMPs) across human cell types, revealing their non-random distribution and role as a novel epigenetic mark affecting gene expression.

Chemotherapeutic 6-thio-2-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex

This study shows 6-thio-dG inhibits telomerase by forming a non-productive complex, affecting telomere maintenance in cancer cells.

OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence

The paper shows that OGG1 and MUTYH repair activities are required for telomeric 8-oxoguanine-induced cellular senescence, with their loss reducing senescence and telomere dysfunction.

Telomeric 8-oxoguanine drives rapid premature senescence in the absence of telomere shortening

This study shows that telomeric 8-oxoguanine induces premature senescence without telomere shortening by causing replication stress and dysfunction.