Mark Hedglin

This study identifies a novel mechanism by which a bivalent E2:RING E3 complex facilitates E2 charging through competitive inhibition and accelerated release of charged E2.

This study presents a cryo-EM structure of the human CTF18-RFC complex bound to PCNA, revealing structural features important for PCNA loading and Pol ε-mediated leading strand synthesis.

This study investigates the interplay between DNA damage tolerance pathways by comparing PCNA occupancy and RPA/Rad51 exchange at stalled replication sites.

This study shows that replication fork reversal is essential for maintaining epigenetic inheritance under replication stress by preventing nucleosome loss and ensuring histone transfer.

This study shows human pol δ holoenzymes can bypass various lesions with insertion and extension efficiencies ranging from 0 to 100%.

This study shows 6-thio-dG inhibits telomerase by forming a non-productive complex, affecting telomere maintenance in cancer cells.

The paper determines structures of bacterial RNA polymerase during reiterative transcription and reveals mechanisms of RNA slippage and product length determination at two promoters.