Cancer BiologybioRxivPreprint
Chemotherapeutic 6-thio-2-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex
Samantha L. Sanford, Mareike Badstübner, Michael H. Gerber…·Patricia Lynn Opresko
This study shows 6-thio-dG inhibits telomerase by forming a non-productive complex, affecting telomere maintenance in cancer cells.