Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput
Patrick H. Kennedy, Amin Alborzian Deh Sheikh, Matthew Balakar, Alexander Curtis Jones, Meagan E. Olive, Mudra Hegde, Maria I. Matias, Natan Pirete, Rajan A. Burt, Jonathan Ma Levy, Tamia Little, Patrick G. Hogan, David R. Liu, John G. Doench, Alexandra C. Newton, , Samuel A. Myers
The paper uses base editor screens to assess phosphorylation site functionality in T cell activation, identifying novel sites that modulate transcriptional activity and signaling pathways.
bioRxiv · Nov 11, 2023 · PreprintSystems Biology