Jonathan Ma Levy

Systematic empirical evaluation of individual base editing targets: validating therapeutic targets in USH2A and comparison of methods

The paper evaluates base editing efficiency for USH2A mutations using in vitro screening and a mouse model, showing high correction rates and comparing methods.

Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput

The paper uses base editor screens to assess phosphorylation site functionality in T cell activation, identifying novel sites that modulate transcriptional activity and signaling pathways.

Programmable large DNA deletion, replacement, integration, and inversion with twin prime editing and site-specific recombinases

This paper introduces twin prime editing (twinPE) and its combination with site-specific recombinases to enable precise DNA deletion, replacement, integration, and inversion in human cells without double-strand breaks.