Non-canonical TLR signaling restricts cytosolic LPS detection.
Shriram Ramani, Sara E. Cahill, Matthew Finnegan, Laurel Stine, Abigail Sondrini, Kiera Clayton, Liraz Shmuel-Galia, Fiachra Humphries
This study identifies MARCO as a decoy LPS sensor regulated by non-canonical TLR signaling, which restricts inflammasome activation and prevents excessive inflammation.
The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology