Oncogenic ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture
Ana-Maria Gherghelas, Natalia Fili, Adam Boulger, Alison E. Twelvetrees, Lin Wang, Lewis Frame, Jamieson Anthony Leyland Howard, Matthew Newton, Mark C. Leake, Christopher P. Toseland
This study shows ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture, supporting endocrine resistance and tumour progression.
bioRxiv · Oct 2, 2026 · PreprintCell Biology