Author

Lewis Frame

University of York

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

Mark C. LeakeiD· 3 shared Alex L. Payne-DwyeriD· 2 shared Jack W ShepherdiD· 2 shared Aakash BasuiD· 1 shared Adam Boulger· 1 shared Agnes NoyiD· 1 shared Aisha H. SyedaiD· 1 shared Alison E. TwelvetreesiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

Mark C. LeakeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Oncogenic ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture

Ana-Maria Gherghelas, Natalia Fili, Adam Boulger, Alison E. Twelvetrees, Lin Wang, Lewis Frame, Jamieson Anthony Leyland Howard, Matthew Newton, Mark C. Leake, Christopher P. Toseland

This study shows ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture, supporting endocrine resistance and tumour progression.

bioRxiv · Oct 2, 2026 · PreprintCell Biology

DNA gyrase in live bacteria forms liquid condensates through weak multivalent bonding of excess GyrB

Aisha H. Syeda, Katy Hollands, Lewis Frame, Jack W Shepherd, Alex L. Payne-Dwyer, Eleanor Goffee, Nicolas P. Burton, Aakash Basu, Agnes Noy, Tony Maxwell, Mark C. Leake

Live E. coli gyrase clusters hold excess GyrB (B:A 2.5:1), show hexanediol-sensitive liquid-like turnover, and docking suggests GyrB bridges heterotetramers.

bioRxiv · Aug 19, 2026 · PreprintBiophysics✦ In-depth digest

Sticker number modulates pyrenoid condensate assembly to support algal fitness

Gaurav Kumar, James Barrett, Philippe Van der Stappen, Alex L. Payne-Dwyer, Onyou Nam, Jack W Shepherd, Lewis Frame, Jamieson A. L. Howard, Vuk Malis, Clément Dégut, Michael R. Hodgkinson, Ralf P. Richter, Charley Schaefer, Michael J. Plevin, Maria Hondele, , Luke C. M. Mackinder

This study shows that varying the number of binding motifs in a disordered protein affects pyrenoid assembly and algal fitness.

bioRxiv · Jan 29, 2026 · PreprintCell Biology