Lin Wang

This study shows ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture, supporting endocrine resistance and tumour progression.

This study identifies myosin VI as a regulator of DNA double-strand break repair, linking ATM signalling to Ku-associated DNA-end stabilisation and suggesting potential therapeutic targeting.

The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.

This paper describes a method using a Vesicle Nucleating Peptide (VNp) to produce recombinant extracellular vesicles in E. coli that are distinct from natural OMVs, enabling efficient protein production and purification.

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

This paper describes a system for producing functional recombinant proteins in extracellular vesicles from E. coli, achieving high yields and enabling continuous isolation.