Author

Natalia Fili

University of SheffieldORCID 0000-0002-0898-0766Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Christopher P. ToselandiD· 3 shared Lin WangiD· 3 shared Alexander W. CookiD· 2 shared Ana-Maria Gherghelas· 2 shared Isabel W. Shahid-Fuente· 2 shared Jesse AaroniD· 2 shared Teng‐Leong ChewiD· 2 shared Abdulmohsen AlanaziiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Christopher P. ToselandORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Oncogenic ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture

Ana-Maria Gherghelas, Natalia Fili, Adam Boulger, Alison E. Twelvetrees, Lin Wang, Lewis Frame, Jamieson Anthony Leyland Howard, Matthew Newton, Mark C. Leake, Christopher P. Toseland

This study shows ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture, supporting endocrine resistance and tumour progression.

bioRxiv · Oct 2, 2026 · PreprintCell Biology

Nuclear Myosin VI stabilises Ku-associated DNA ends during non-homologous end joining

Abdulmohsen Alanazi, Alexander W. Cook, Isabel W. Shahid-Fuente, Natalia Fili, Tomáš Venit, Ana-Maria Gherghelas, Noah Hitchcock, Alexandra Moreno Mitchell, Jesse Aaron, Teng‐Leong Chew, Lin Wang, Piergiorgio Percipalle, Christopher P. Toseland

This study identifies myosin VI as a regulator of DNA double-strand break repair, linking ATM signalling to Ku-associated DNA-end stabilisation and suggesting potential therapeutic targeting.

bioRxiv · Sep 2, 2026 · PreprintCancer Biology

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells.

Yukti Hari‐Gupta, Danielle Lambert, Isabel W. Shahid-Fuente, Natalia Fili, Ália dos Santos, Alexandria R. Sprules, Hyejeong Rosemary Kim, Alexander W. Cook, Peter J. I. Ellis, Jesse Aaron, Teng‐Leong Chew, Lin Wang, Christopher P. Toseland

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

bioRxiv · Nov 13, 2025 · PreprintCancer Biology