Author

Matthew R. Burrell

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Francesca CeroniiD· 2 shared George ThomiD· 2 shared Carl I. WebsteriD· 1 shared Cleo KontoravdiiD· 1 shared Frank AbendrothiD· 1 shared Ian K. Gurrell· 1 shared Jacopo GabrielliiD· 1 shared Jessica StoodleyiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Francesca CeroniORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion

Jacopo Gabrielli, Marino Exposito-Rodriguez, Justina Briliute, Matthew R. Burrell, George Thom, Cleo Kontoravdi, Francesca Ceroni

STAMPS designs novel mammalian signal peptides to enhance protein secretion, outperforming existing benchmarks in multiple cell lines.

bioRxiv · Nov 20, 2025 · PreprintSynthetic Biology

Billion-Scale Deciphering of Human Gene Regulatory Grammar

Joshua Mayne, Marino Exposito Rodriguez, Matthew R. Burrell, Francesca Ceroni, Stephen Goldrick

The paper introduces a scalable platform to generate large-scale sequence-to-expression datasets in human cells and trains deep learning models to predict gene expression from DNA sequences.

bioRxiv · Nov 10, 2025 · PreprintSynthetic Biology

Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy

Suzan M. Hammond, Frank Abendroth, Larissa Goli, Matthew R. Burrell, George Thom, Ian K. Gurrell, Jessica Stoodley, Nina Ahlskog, Michael John Gait, Matthew J. A. Wood, Carl I. Webster

This study demonstrates that systemic delivery of ASO conjugated to a brain-targeting antibody improves SMN2 splicing and survival in SMA mouse models.

bioRxiv · Jul 29, 2021 · PreprintMolecular Biology