Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity
Julia V McCarthy, A. Christina Heroven, King Ifashe, Martin Fellermeyer, Dan Hudson, Raul Cioaca, Max N Quastel, Yunkai Yang, Matteo Cagiada, Simeon D. Dragonov, Christopher J. Thorpe, Adán Pinto-Fernández, Alexander Greenshields‐Watson, Gillespie, Charlotte Mary Deane, Ricardo A. Fernandes
The paper reverse-engineers a TCR to reduce cross-reactivity while maintaining potency by reverting specific residues.
bioRxiv · May 6, 2026 · PreprintImmunology