Author

Martin Fellermeyer

Chinese Academy of Medical Sciences & Peking Union Medical CollegeORCID 0000-0002-1823-736XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Christina HeroveniD· 1 shared Adán Pinto-FernándeziD· 1 shared Alexander Greenshields‐WatsoniD· 1 shared Ana Mafalda SantosiD· 1 shared Ben de WetiD· 1 shared Bin FuiD· 1 shared Bing LiiD· 1 shared Charlotte Mary DeaneiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

A. Christina HerovenORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity

Julia V McCarthy, A. Christina Heroven, King Ifashe, Martin Fellermeyer, Dan Hudson, Raul Cioaca, Max N Quastel, Yunkai Yang, Matteo Cagiada, Simeon D. Dragonov, Christopher J. Thorpe, Adán Pinto-Fernández, Alexander Greenshields‐Watson, Gillespie, Charlotte Mary Deane, Ricardo A. Fernandes

The paper reverse-engineers a TCR to reduce cross-reactivity while maintaining potency by reverting specific residues.

bioRxiv · May 6, 2026 · PreprintImmunology

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

Mateusz Kotowski, Daniel F. Heraghty, Markus Körbel, Debasis Banik, Ziwei Zhang, Shekhar Kedia, Bin Fu, James T. McColl, Bing Li, Joseph Clarke, Martin Fellermeyer, Yuan Lui, Giovanna Bossi, David K. Cole, Haoqi Chen, , Simon J. Davis

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

bioRxiv · Aug 29, 2025 · PreprintImmunology