Author

Raul Cioaca

Chinese Academy of Medical Sciences & Peking Union Medical College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ricardo A. FernandesiD· 2 shared Yunkai YangiD· 2 shared A. Christina HeroveniD· 1 shared Adán Pinto-FernándeziD· 1 shared Alexander Greenshields‐WatsoniD· 1 shared Alexander J. MentzeriD· 1 shared Caner AkıliD· 1 shared Charlotte Mary DeaneiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Ricardo A. FernandesORCID

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2 papers

Recent·Most cited

Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity

Julia V McCarthy, A. Christina Heroven, King Ifashe, Martin Fellermeyer, Dan Hudson, Raul Cioaca, Max N Quastel, Yunkai Yang, Matteo Cagiada, Simeon D. Dragonov, Christopher J. Thorpe, Adán Pinto-Fernández, Alexander Greenshields‐Watson, Gillespie, Charlotte Mary Deane, Ricardo A. Fernandes

The paper reverse-engineers a TCR to reduce cross-reactivity while maintaining potency by reverting specific residues.

bioRxiv · May 6, 2026 · PreprintImmunology

Uncovering structural determinants of peptide recognition by public and private T-cell receptors

Caner Akıl, Yanchun Peng, Julia McCarthy, Yanan Zhu, Nathan J. Hardenbrook, Danning Dong, Elie Antoun, Xuan Yao, Guihai Liu, Ji-Li Chen, Esra Balıkçı, Raul Cioaca, Yunkai Yang, Alexander J. Mentzer, Julian Charles Knight, , Peijun Zhang

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

bioRxiv · Nov 23, 2025 · PreprintImmunology