Author

Yunkai Yang

Chinese Academy of Medical Sciences & Peking Union Medical CollegeORCID 0000-0002-2240-807XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Raul Cioaca· 2 shared Ricardo A. FernandesiD· 2 shared A. Christina HeroveniD· 1 shared Adán Pinto-FernándeziD· 1 shared Alexander Greenshields‐WatsoniD· 1 shared Alexander J. MentzeriD· 1 shared Caner AkıliD· 1 shared Charlotte Mary DeaneiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Raul Cioaca

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity

Julia V McCarthy, A. Christina Heroven, King Ifashe, Martin Fellermeyer, Dan Hudson, Raul Cioaca, Max N Quastel, Yunkai Yang, Matteo Cagiada, Simeon D. Dragonov, Christopher J. Thorpe, Adán Pinto-Fernández, Alexander Greenshields‐Watson, Gillespie, Charlotte Mary Deane, Ricardo A. Fernandes

The paper reverse-engineers a TCR to reduce cross-reactivity while maintaining potency by reverting specific residues.

bioRxiv · May 6, 2026 · PreprintImmunology

Uncovering structural determinants of peptide recognition by public and private T-cell receptors

Caner Akıl, Yanchun Peng, Julia McCarthy, Yanan Zhu, Nathan J. Hardenbrook, Danning Dong, Elie Antoun, Xuan Yao, Guihai Liu, Ji-Li Chen, Esra Balıkçı, Raul Cioaca, Yunkai Yang, Alexander J. Mentzer, Julian Charles Knight, , Peijun Zhang

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

bioRxiv · Nov 23, 2025 · PreprintImmunology