Two-Step Mechanism of Bruton's Tyrosine Kinase MembraneRecruitment and Activation
Rachel A. McAllister, Amy L. Stiegler, Keerthana Chari, Meera Chari, Moitrayee Bhattacharyya, Kallol Gupta
This paper uses native mass spectrometry to show BTK recruits to membranes via phosphatidylserine and is activated by PIP3, proposing a two-step mechanism for membrane recruitment and activation.
Proceedings of the National Academy of Sciences · Jun 29, 2026Peer-reviewedBiophysics