Author

Rachel McAllister

Yale UniversityORCID 0000-0002-1646-7241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Kallol GuptaiD· 3 shared Moitrayee BhattacharyyaiD· 2 shared Amy L. StiegleriD· 1 shared Aniruddha PandaiD· 1 shared Caroline BrowniD· 1 shared Catherine L Pontius· 1 shared Daehun ParkiD· 1 shared Eric I. Sun· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

Kallol GuptaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Two-Step Mechanism of Bruton's Tyrosine Kinase MembraneRecruitment and Activation

Rachel A. McAllister, Amy L. Stiegler, Keerthana Chari, Meera Chari, Moitrayee Bhattacharyya, Kallol Gupta

This paper uses native mass spectrometry to show BTK recruits to membranes via phosphatidylserine and is activated by PIP3, proposing a two-step mechanism for membrane recruitment and activation.

Proceedings of the National Academy of Sciences · Jun 29, 2026Peer-reviewedBiophysics

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

Mukesh Kumar, Yumei Wu, Justin L. Knapp, Catherine L Pontius, Daehun Park, Rose Witte, Rachel McAllister, Kallol Gupta, Kartik N. Rajagopalan, Pietro V. De Camilli, Timothy A. Ryan

The paper shows that DDHD2 is essential for neurons to use fatty acids from lipid droplets as an energy source during activity when glucose is unavailable.

Nature Metabolism · Jul 1, 2025Peer-reviewedNeuroscience

A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs

Caroline Brown, Snehasish Ghosh, Rachel McAllister, Mukesh Kumar, Gerard Walker, Eric I. Sun, Talat Aman, Aniruddha Panda, Shailesh Kumar, Wenxue Li, Jeff Coleman, Yansheng Liu, James E. Rothman, Moitrayee Bhattacharyya, Kallol Gupta

This paper introduces a platform for high-throughput extraction of membrane proteins into native nanodiscs while preserving their local membrane context and provides a database for optimized extraction conditions.

Nature Methods · Nov 28, 2024Peer-reviewedBiophysics