Amy L. Stiegler

This paper uses native mass spectrometry to show BTK recruits to membranes via phosphatidylserine and is activated by PIP3, proposing a two-step mechanism for membrane recruitment and activation.

This paper reports a unique crystal structure of the c-Src SH3 domain mediated by nickel ions, revealing a 2:2 stoichiometry and dimerization mechanism.

This study shows the C2 domain enhances Ras GTPase activating protein catalytic activity by interacting with the Ras allosteric lobe, as demonstrated through structural analysis and mutation studies in mice and SynGAP.