A Dimeric Rocaglate Promotes Multivalent eIF4A-RNA Assembly
Jie Liu, Megan K. Moore, Kevin Lou, Douglas R. Wassarman, Abolfazl Arab, Samuel Ojeda, Barbara Karakyriakou, Ann-Sophie Koglin, Christopher J. Ott, Luke A. Gilbert, Kevan M. Shokat
This paper identifies BisRoc, a dimeric rocaglate ligand that suppresses translation more potently and specifically than monomeric RocA by promoting multivalent eIF4A-RNA assembly.
bioRxiv · Mar 10, 2026 · PreprintBiochemistry