Barbara Karakyriakou

This study identifies DNA methylation alterations in tumor endothelial cells using bulk specimens and deconvolution methods, revealing potential therapeutic targets in breast cancer.

This paper identifies BisRoc, a dimeric rocaglate ligand that suppresses translation more potently and specifically than monomeric RocA by promoting multivalent eIF4A-RNA assembly.

DrugMap quantitatively analyzes cysteine ligandability across 416 cancer cell lines, revealing redox state, conformational changes, and mutations as drivers of variability, and identifies covalent inhibitors targeting NFκB1 and SOX10.