Inhibition of Gasdermin D by Disulfiram Attenuates Cardiac Inflammation and Fibrosis following Ischaemia Reperfusion Injury
Judy S.Y. Choi, Mehnaz Pervin, Helen Kiriazis, Parvin Yavari, Aascha Brown, Man K.S. Lee, Andrew James Murphy, Daniel G. Donner, James Edward Vince, Arpeeta Sharma, Judy B. de Haan
This paper shows that Disulfiram reduces cardiac inflammation and fibrosis after heart attack by inhibiting the GSDMD pathway.
bioRxiv · Mar 12, 2026 · PreprintImmunology