Coronary Artery Disease risk variant dampens the expression of CALCRL by reducing HSF binding to shear stress responsive enhancer in endothelial cells
Ilakya Selvarajan, Miika Kiema, Ru‐Ting Huang, Jin Li, Jiayu Zhu, Petri Pölönen, Tiit Örd, Kadri Õunap, Mehvash Godiwala, Anna K. Golebiewski, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K. Stolze, Maximiliano Arce, , Minna Unelma Kaikkonen
The paper identifies a CAD risk SNP rs880890 in an endothelial enhancer that reduces CALCRL expression by impairing HSF binding under shear stress.
Arteriosclerosis Thrombosis and Vascular Biology · Apr 11, 2024Peer-reviewedGenetics