Author

Johanna P. Laakkonen

University of Eastern FinlandORCID 0000-0002-8556-9727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Miika KiemaiD· 2 shared Minna Kaikkonen-MäättäiD· 2 shared Tiit ÖrdiD· 2 shared Aarthi RavindraniD· 1 shared Anna K. GolebiewskiiD· 1 shared Anu ToropaineniD· 1 shared Aydın BölükiD· 1 shared Casey E. RomanoskiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenomics

Miika KiemaORCID

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Author profile →

2 papers

Recent·Most cited

Transcriptomic, Specific Marker, and Pathway Analysis of Smooth Muscle Cell Foam Cells Relative to Macrophage Foam Cells in Human Atherosclerosis

Sima Allahverdian, Yuancheng Mao, Pinhao Xiang, Valentin Blanchard, Aydın Bölük, Patrick Hart, Paul P. Cheng, Daniel Yuhang Li, Matthew D. Worssam, Uma Thanigai Arasu, Mari Taipale, Miika Kiema, Johanna P. Laakkonen, Tiit Örd, Minna Kaikkonen-Määttä, , Gordon A. Francis

Smooth muscle foam cells in early-to-intermediate human coronary plaques map to fibromyocytes, express CFH and SERPINE1 unlike macrophage foam cells, and show matrix, coagulation and angiogenesis programs.

bioRxiv · Aug 1, 2026 · PreprintGenomics✦ In-depth digest

Coronary Artery Disease risk variant dampens the expression of CALCRL by reducing HSF binding to shear stress responsive enhancer in endothelial cells

Ilakya Selvarajan, Miika Kiema, Ru‐Ting Huang, Jin Li, Jiayu Zhu, Petri Pölönen, Tiit Örd, Kadri Õunap, Mehvash Godiwala, Anna K. Golebiewski, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K. Stolze, Maximiliano Arce, , Minna Unelma Kaikkonen

The paper identifies a CAD risk SNP rs880890 in an endothelial enhancer that reduces CALCRL expression by impairing HSF binding under shear stress.

Arteriosclerosis Thrombosis and Vascular Biology · Apr 11, 2024Peer-reviewedGenetics